洋金花倍半萜类化合物的分离与鉴定

摘要

Objective:To investigate the compounds of sesquiterpenoids from Dature metel L..Methods:A variety of col-umn chromatography such as ion exchange resins, macroporous resins and silica gel was used in the isolation, and spec-tral analysis was adopted to determine the chemical structures of flavonoids.Results:Five sesquiterpenoids were isolated from Dature metel L., dihydrophaseic acid (1), (6Z)-4-(3-hydroxy-butylidene) -3,5,5-trimethyl-2-cy-clohexene-1-one-O-β-D-glucopyranoside (2), (6E) -4-(3-hydroxybutylidene) -3,5,5-trimethyl-2-cyclohexene-1-one-O-β-D-glucopyranoside (3) , Vomifoliol (4) and (6S,9R)-3-oxo-α-ionol-9-O-β-D-gluco-pyranoside (5) .Conclusion:Compounds 1-3 are first isolated from this plant.%目的：研究洋金花中倍半萜类化学成分。方法：采用离子交换树脂、大孔吸附树脂、硅胶等柱色谱方法分离，利用多种波谱学测试技术进行化合物的结构鉴定。结果：从洋金花中分离并鉴定了5个倍半萜类化合物，分别为二氢红花菜豆酸（dihydrophaseic acid）（1），（6Z）－4－（3－hydroxybutylidene）－3，5，5－trimethyl－2－cyclohexene－1－one－O－β－D－glucopyranoside （2），（6E）－4－（3－hydroxy-butylidene）－3，5，5－trimethyl－2－cyclohexene－1－one－O－β－D－glucopyrano－side （3），Vomifoliol （4）和（6S，9R）－3－oxo－α－ionol－9－O－β－D－glucopyranoside （5）。结论：化合物1－3为首次从洋金花中分离得到。