In recent years, brominated flame retardants (BFRs), one of the most widely used flame retardants in the polymer and the fabric widely are used in various consumers and industrial products. BFRs are persistent organic pollutants which has been widespread in the environment and has attracted wide international attention. As the use of BFRs increasing year by year, BFRs have been widely detected and showed varying degrees of toxic effects on aquatic animals, birds and mammals, the breadth of its distribution, refractory and uncertainty in human health has attracted people's attention. Based on results of animal toxicology studies abroad, the article discussed the effects of BFRs and their metabolites on endocrine disrupting activity of different animals, mainly on the level of thyroid hormone, estrogen , androgen levels and the development of animal nervous systems, and provided a theoretical basis for evaluation of BFRs on the impact of animal and human health.%近年来,防火溴系阻燃剂(Brominated flame retardants,BFRs)是在聚合物和织物中应用最为广泛的阻燃剂之一,广泛应用于各种家用和工业产品.BFRs属持久性有机污染物,目前在环境中已普遍存在,已在国际上引起了广泛的关注.由于BFRs的使用量在逐年增大,在土壤、沉积物、大气和生物体中普遍检测出 BFRs.BFRs对水生动物、鸟类、哺乳动物都存在不同程度的毒害作用,其分布的广泛性、难降解性和对人体健康的不确定性已引起人们的普遍关注.基于国外动物毒理学研究成果,文章综合论述了BFRs及其代谢化合物对不同动物的内分泌干扰活性,主要介绍了对甲状腺激素水平、雌激素水平、雄激素水平及对动物神经系统发育的影响,为评价BFRs对动物和人类的健康影响提供理论基础.
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