听觉词语学习测验对阿尔茨海默病的诊断价值

摘要

Objective To assess the validity of World Health Organization-University of California-Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) in the diagnosis of Alzheimer's disease (AD). Methods Using WHO-UCLA AVLT, we assessed 183 AD patients (AD group) , 1283 subjects with normal cognitive status (normal control group) , and 134 individuals suffered from other diseases easy to be confused wilh AD (confused control group). Results The AVLT score was 40. 9 ± 0. 3 in normal control group, 30.7 ± 0. 9 in confused control group, 16. 6 ± 1. 0 in mild AD group, and 10. 2 ± 1.2 in moderate AD group after adjustment for educational level, age, sex, and rural/urban residence ( all P <0. 05 ). With the 5th percentage of the overall score as the cutoff point, this tool showed a sensitivity of 86. 3% and a specificity of 93. 3%. Conclusion WHO-UCLA CVLT is highly sensitive and specific in the diagnosis of AD.%目的 评估世界卫生组织-加州大学洛杉矶分校听觉词语学习测验( WHO-UCLA AVLT)量表对阿尔茨海默病(AD)的诊断价值.方法 采用WHO-UCLA AVLT量表,对183例AD患者(病例组)进行检测,并与1283名认知正常者(正常组)和134名可能与AD混淆的其他疾病患者(混淆组)进行比较.结果 经协方差分析对年龄、性别、文化程度进行修正后,正常组、混淆组、轻度AD组和中度AD组WHO-UCLA AVLT得分的校正均数分别为40.9±0.3、30.7±0.9、16.6±1.0、10.2±1.2,各组间两两相比差异均有统计学意义(P均＜0.05).以量表总分第5百分位数为分界值,本量表对AD诊断的敏感性为86.3％,特异性为93.3％.结论 WHO-UCLA AVLT量表具有较高的敏感性和特异性,可用于AD诊断.