长链非编码RNA调控成骨分化作用机制的研究进展

摘要

The osteogenic differentiation is a complex dynamic balance involving the participations of human mesenchymal stem cells,adipose-derived stem cells,human periodontal ligament cells,pre-osteoblasts,osteoblasts and so on.As a kind of non-coding RNA with their transcripts of more than 200 bp in length,the long noncoding RNA (LncRNA) plays important roles as a regulatory molecule in a variety of mechanisms.Recent studies show that LncRNA also plays vital role in the osteogenic differentiation.In this review,we focus on the researches of regulation role of LncRNA on osteogenic differentiation in different cells and further introduce the progress in this area,expecting to provide basis for the following studies.%成骨分化是一个复杂的动态平衡过程,参与成骨分化过程的细胞主要包括人类间充质于细胞、脂肪干细胞、前成骨细胞、人牙周膜干细胞和成骨细胞等.长链非编码RNA是一类转录本长度大于200 bp的非编码RNA,可作为人类基因组中一类重要的调控分子通过多种方式发挥其生物学功能,其在成骨分化过程中也起着重要调控作用.本文重点概述长链非编码RNA调控成骨分化过程的作用机制及研究进展,以期为相关研究提供思路.