子宫内膜异位症相关卵巢恶性肿瘤病理研究进展

摘要

子宫内膜异位症恶变的主要病理类型有苗勒上皮性癌、子宫内膜样间质肉瘤等,在卵巢中以子宫内膜样癌、透明细胞癌等最常见.子宫内膜异位症相关卵巢恶性肿瘤的发生发展可能涉及到多条分子通路如Wnt/β-catenin信号通路、MAPK信号通路、PI3K/Akt/mTOR信号通路等的改变,通路中关键基因β-catenin、MAPK、PIK3CA、ARID1A等协同作用,激活相应的下游信号通路,促进肿瘤的发生发展.本文主要对子宫内膜异位症恶变及其相关卵巢恶性肿瘤的临床病理特征及分子病理特点进行综述.%The main pathological types of malignant transformation of endometriosis are mullerian epithelial carcinoma, endometrioid stroma sarcoma, etc., and the most common entities in ovary are endometrioid carcinoma and clear cell carcinoma. The development of endometriosis-related ovarian cancer may involve various molecular pathways, such as Wnt/β-catenin signaling pathway, MAPK signaling pathway, PI3K/Akt/mTOR signaling pathways and so on. The synergy effect among key genes on pathways, sucn asβ-catenin, MAPK, PIK3CA, ARID1A and others, activates the corresponding downstream signaling pathways, and promotes tumors development. Herein, the malignant transformation of endometriosis and its underlining molecular mechanism, the clinicopathological characteristics of endometriosis related ovarian malignancies will be reviewed and discussed.