Elevated Lactate Production and Carbohydrate Metabolism Following Combined Exercise Training in Early Breast Cancer Survivors: A Retrospective Study

摘要

Differences in metabolic function between breast cancer (BCa) survivors and sedentary-healthy controls (HC) were assessed using a maximal cardiopulmonary exercise test (CPET) before and after a 16-week community-based exercise training program. Thirty-four BCa survivors and 21 HC enrolled at baseline, with 31 and 15 participants completing the intervention, respectively. At baseline, respiratory exchange ratio (RER) did not differ between groups. However, 3-minute blood lactate (3MBL) trended to be higher in HC (p=0.072). Following training, there were no changes in RER or between groups, although all change scores were positive. 3MBL trended to increase across training (p=0.075). Regression modeling suggested exercise intensity as a quadratic function was the strongest predictor of RER measurements (all p0.001), while training had a small but significant impact (p0.001). In this preliminary analysis, lactate production and carbohydrate reliance may increase in BCa survivors following exercise training, but needs confirmation using larger sample sizes.