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Design of miniature microscope objective optics for biomedical imaging.

机译:用于生物医学成像的微型显微镜物镜光学器件的设计。

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摘要

The topic of this dissertation is on the design and construction of miniature microscope objective optics. The design of miniature microscope objective is both similar and different from conventional microscope objective. The design and construction of two miniature microscope objectives are presented in this dissertation. The first one is a high numerical aperture (NA), water-immersion objective and it is a part of a fiber confocal reflectance microscope (FCRM). The second one is a moderate NA dry objective and it is a part of a miniature microscope array (MMA). The capability, complexity and fabrication method of the two miniature objectives are different but they both share some similar design traits as result of their miniaturization. FCRM's miniature objective has a NA of 1.0 and it is designed to operate at near infrared λ = 1,064 nm. It is 7 mm in outer diameter and 21 mm in length (measured from object plane to image plane). This kind of dimension is approximately 10 times smaller than a conventional microscope objective of similar caliber. Sub-micrometer resolution has been experimentally demonstrated with this miniature objective. MMA's miniature objective has a NA of 0.4 and it is designed to operate over the visible spectrum. It is 1.2 mm in diameter and 9.4 mm in length. The image quality of MMA's miniature objective is experimentally demonstrated to be comparable to the state-of-art commercial microscope objective.
机译:本文的主题是微型显微镜物镜的设计与制造。微型显微镜物镜的设计与常规显微镜物镜既相似又不同。本文介绍了两个微型显微镜物镜的设计与构造。第一个是高数值孔径(NA),水浸物镜,它是光纤共焦反射显微镜(FCRM)的一部分。第二个是中等NA干物镜,它是微型显微镜阵列(MMA)的一部分。两个微型目标的能力,复杂性和制造方法不同,但是由于它们的小型化,它们都具有一些相似的设计特征。 FCRM的微型物镜的NA为1.0,设计用于近红外λ= 1,064 nm。外径为7毫米,长度为21毫米(从物平面到像平面测量)。这种尺寸比类似口径的常规显微镜物镜小大约10倍。通过这个微型物镜,实验证明了亚微米分辨率。 MMA的微型物镜的NA为0.4,设计用于在可见光谱范围内工作。直径为1.2毫米,长度为9.4毫米。 MMA微型物镜的图像质量已通过实验证明与先进的商用显微镜物镜相当。

著录项

  • 作者

    Liang, Chen.;

  • 作者单位

    The University of Arizona.;

  • 授予单位 The University of Arizona.;
  • 学科 Physics Optics.; Biophysics Medical.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 142 p.
  • 总页数 142
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 光学;生物物理学;
  • 关键词

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