DISCOVERING BRAIN MECHANISMS AND THE RULES OF MOLECULAR BIOLOGY

摘要

The human genome has approximately 30,000 genes. Brain cells express at least 15,000. The human brain is subject to many acute and chronic diseases including viral encephalitis, AIDS/HIV Associated Dementia, Alzheimer's disease, and Huntington's disease. Each disease involves temporal and spatial brain gene expression and many genes have been identified involved in these diseases over several decades of research. However, with the advent of the new large-scale laboratory specimen gene expression (Microarrays) and information processing (Bioinformatics) methodologies, our data acquisition and analysis are greatly accelerated. We need to understand the mechanisms of gene expression in the diseased brain compared to the normal brain in order to begin to develop proper molecular models for brain disease processes and thus ultimately curing these diseases. In order to carry out a project involving the human brain crucial aspects involve the tissue itself, the RNA produced the choice of many types of controls, and then the Bioinformatics procedures used. The clinical information that comes with tissue is crucial because only then can accurate disease states enter into the data analysis.