Human Erythrocyte Hemolysis Induced by Bioinspired Sugar Surfactants

摘要

Hemolytic activity of single-head single-tail non-ionic saccharide - derived surfactants (i.e., N-alkanoyl-iV-methyllactitolamines and N-alkyl-Af-methylaldonylamides) as well as dicephalic (i.e., (N-dodecyl-A?,./V-bis[(3-D-aldony-lamido)propyl]amines; aldonyl = gluconyl and lactobionyl) and gemini structures (i.e., N,N'-bisdodecyl-N,N'-bis[(3-aldonylamide)propyl]ethylenediamines; aldonyl = gluconyl and lactobionyl) were examined and discussed in relation to both their critical micelle concentration (CMC) values, and structural aspects. The red blood cells lysis is found to depend on the surfactants structure and the hydrophobic tail length, as well as to correlate well with the CMC magnitudes.