NOVEL pH-RESPONSIVE POLYPHOSPHOESTER-BASED HYDROGELS WITH FAST GELATION

摘要

pH-Responsive polyphosphoester (PPE)-based hydrogels with rapid gelation were fabricated and evaluated for drug delivery application. Rheological studies indicated that the gelation occurs mainly due to the synergistic effect of ammonium persulfate (APS) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). The hydrogels exhibited favorable pH-dependent swelling behavior and the swelling ratio changed regularly with the PPE content. The drugs loaded into the hydrogels during the gelation could be released continuously from the hydrogels.