原子转移自由基法一锅合成具有pH响应性的新型糖聚合物

摘要

New pH-responsive glycopolymers were designed and synthesized by atom transfer radical polymerization. The architectures of the glycopolymers were confirmed by 1H NMR and Gel permeation chromatography (GPC). Dynamic light scattering(DLS) and Drop shape analysis(DSA) tests were also performed to investigate the solution properties of the glycopolymer. This new glycopolymer contains a polyelectrolyte block and exhibits tunable pH-responsibility in water.%糖聚合物由于具有较好的亲水性和生物活性而成为生物医药等领域的研究热点[1].近年来,研究人员也开始将具有环境响应性质的聚合物接在糖聚合物上构成多嵌段含糖共聚物[2～4],将其作为新型的智能药物载体[5].然而,糖聚合物的合成具有一定的难度[6,7].本文利用原子转移自由基聚合法(ATRP),简单地一锅(“One -pot”)合成了具有pH响应性的糖聚合物,并且仅通过控制甲基丙烯酸-2-二甲氨基乙酯(DMAEMA)和甲基丙烯酸-2-二乙氨基乙酯(DEAEMA)单体的投料比即可实现对糖聚合物胶束的临界pH转变点在人体生理pH值附近的调节.此外,糖聚合物中的P(DMAEMA-co-DEAE-MA)嵌段在一定条件下为带正电荷的聚电解质.因此,所合成的糖聚合物不但可以用作传统药物的载体,还可望成为带有负电荷的新型药物如单链DNA(ssDNA)[8]等的载体.