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首页> 外文会议>Symposium on innovative polymers for controlled delivery: Abstract book. >SYNTHESIS OF OLIGOETHYLENIMINE GRAFTED NET-POLY(AMINO ESTER) AND THEIR APPLICATION IN GENE DELIVERY
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SYNTHESIS OF OLIGOETHYLENIMINE GRAFTED NET-POLY(AMINO ESTER) AND THEIR APPLICATION IN GENE DELIVERY

机译：低聚亚乙基亚胺接枝网络淀粉（氨基酯）的合成及其在基因传递中的应用

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摘要

Novel net-polymers were prepared by grafting oligoethylenimine (OEI) on net-poly(amino ester) (N-P-g-OEI) and applied as gene carriers. N-P-g-OEI can effectively condense DNA to form small-sized complex particles (<150 nm). These cationic polymers showed low toxicity due to PEG-containing backbones and the low molecular weight OEI. The results demonstrated that these cationic polymers have much higher transfection efficiency compared to PEI25k in COS-7 cells.
机译：通过将寡乙烯亚胺（OEI）接枝到净聚（氨基酯）（N-P-g-OEI）上来制备新型净聚合物，并将其用作基因载体。 N-P-g-OEI可以有效地凝结DNA以形成小尺寸的复杂颗粒（<150 nm）。这些阳离子聚合物由于含PEG主链和低分子量OEI而显示出低毒性。结果表明，与PEI25k在COS-7细胞中相比，这些阳离子聚合物具有更高的转染效率。

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  • 来源
  • 会议地点 Suzhou(CN);Suzhou(CN)
  • 作者

    Jialiang Xia; Lei Chen; Huayu Tian; Xuesi Chen; Atsushi Maruyama; Tae Gwan Park;

  • 作者单位

    Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China,Graduate University of Chinese Academy of Sciences, Beijing 100049, China;

    Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China,Graduate University of Chinese Academy of Sciences, Beijing 100049, China;

    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea;

    Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;

    Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;

    In;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物材料学;生物材料学;
  • 关键词

    poly(amino ester); biodegradable; oligoethylenimine; gene delivery;

    机译：聚氨基酯;可生物降解;低聚亚乙基亚胺;基因传递;
  • 入库时间 2022-08-26 14:20:03

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