首页>
外国专利>
Pegylated and fatty acid grafted chitosan oligosaccharide, synthesis method and application for drug delivery system
Pegylated and fatty acid grafted chitosan oligosaccharide, synthesis method and application for drug delivery system
展开▼
机译:聚乙二醇脂肪酸接枝的壳聚糖低聚糖,合成方法及在药物递送系统中的应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides a PEGylated and fatty acid grafted chitosan oligosaccharide comprising a structural unit represented by the following Formula (I) and a structural unit represented by the following Formula (II) and synthesize method, wherein the chitosan oligosaccharide has a molecular weight of less than 200,000 Da, and a degree of deacetylation of 70%-100%, and part of free amino groups of chitosan oligosaccharide chain are replaced by a fatty acid or PEG, where n refers to degree of polymerization of the PEG, and R is an alkyl group having 11-21 carbon atoms. The grafting ratio of fatty acids is 1%-50%, and the grafting ratio of PEG is 0.05%-50%. The present invention also comprise a pharmaceutical composition comprising the PEGylated and fatty acid grafted chitosan oligosaccharide as a carrier, and use of the PEGylated and fatty acid grafted chitosan oligosaccharide in preparation of a pharmaceutical composition.; 展开▼