SYNTHESIS OF OLIGOETHYLENIMINE GRAFTED NET-POLY(AMINO ESTER) AND THEIR APPLICATION IN GENE DELIVERY

摘要

Novel net-polymers were prepared by grafting oligoethylenimine (OEI) on net-poly(amino ester) (N-P-g-OEI) and applied as gene carriers. N-P-g-OEI can effectively condense DNA to form small-sized complex particles (<150 nm). These cationic polymers showed low toxicity due to PEG-containing backbones and the low molecular weight OEI. The results demonstrated that these cationic polymers have much higher transfection efficiency compared to PEI25k in COS-7 cells.