EXPERIMENTAL STUDY ON BIODEGRADABLE POLYMER-PACLITEXAL CONJUGATE MICELLES FOR CHEMOTHERAPY OF C6 GLIOMA

摘要

An intracranial C6 glioma model was constructed using Wistar rats. Paclitaxel (PTX) was conjugated to biodegradable diblock copolymer PEG-PLA to form water-soluble PEG-PLA-PTX micelles. The tumor-bearing rats were treated with blank PEG-PLA micelles, commercial Taxol, and PEG-PLA-PTX micelles, respectively, via tail vein injection. With the same equivalent PTX dose, the PEG-PLA-PTX micelles displayed enhanced inhibition ability to tumor growth as shown by the body weight change, survival time and tumor image size. This improved therapeutic effect was ascribed to the EPR effect of the PEG-PLA-PTX micelles. Fluorescent imaging of the brain slice further confirmed that the PEG-PLA-PTX micelles can pass the BBB and remain in the brain even 5 days post drug administration.