An argument for the chicken embryo as a model for the evelopmental toxicological effects of the polyhalogenated aromatic hydrocarbons (PHAHS)

摘要

The choice of an aniaml model is ultimately crucial to toxicological testing. If one does not use the appropriate model for the chemical and endpoint being studied, then the test results may not realy provide the appropriate toxciological information. There are three basic types of animal models: sentinel models, screening models, and mechanistic models. Each of t hese models has specific needs and requirements, some of which overlap, some of which are distinctly different. Therefore, some animal models are more appropriate for evaluating the effects of some chemicals than are other animal models. This article will present the argument that the chicken embryo is especially appropriate as a n animal model for studying the mecanism of the developmental toxicological effects of the polyhalogenated aromatic hydroarbons (PHAHs).