Mechanisms of Cellular Membrane Effects of TCDD (2,3,7,8-Tetrachlorodibenzo-p-Dioxin) Selected Perfluorinated Acids and Polyhalogenated Aromatic Hydrocarbons

摘要

Two model systems were used to examine the phenomenon of metabolic cooperation between cells. The recovery of ARL-TG superscript r cells in the presence of hepatocytes and 6-thioguanine was examined. Perfluorodecanoic acid and 2, 2' 4, 4' 5, 5' hexachlorobiphenyl have significant effects on metabolic cooperation between cells; implying that these chemical interfere with gap junction function and hence interrupt cell-cell communication. These results were confirmed in autoradiographic studies in which the transfer of Tritium uridine between donor and recipient cells was examined. If these compounds inhibit cell-cell communication in vivo, then that may be one mechanism by which the toxic effect is exerted. Keywords: Polychlorinated biphenyls.