Clinical benefits of combined diagnostic three-dimensional digital breast tomosynthesis and ultrasound imaging

摘要

Our goal is to evaluate diagnostic digital breast tomosynthesis and ultrasound imaging clinical value in detecting anddiagnosing early stage breast cancers. Determine if fusion imaging would decrease the number of biopsies and reducefurther patient workup otherwise required to establish a definitive diagnosis. This paper presents the clinical results basedon the study conducted at Helsinki University Central Hospital. Presentation demonstrates clinical dual modality imagesand results. Tomosynthesis of amorphous selenium based full field digital mammography system will be also presented.Forty asymptomatic women enrolled in the study based on prior identification of suspicious findings on screeningmammograms where the possibility of breast cancer could not be excluded. Abnormal screening mammogram findingsincluded tumor-like densities, parenchymal asymmetries and architectural distortions. Eight women were operated and32 were not referred for surgery. Those cases, which were operated, three lesions represented ductal carcinoma in situ,two ductal carcinomas, one atypical ductal hyperplasia, one fibroadenoma and one radial scar. The 32 not operated casesrevealed to be benign or superimposition of normal parenchymal breast tissue. The cases were returned to biennialscreening. Ultrasound did not show clearly any lesions, but using tomosynthesis and ultrasound together we were able toanalyze and locate the lesions exactly. Special tomosynthesis improves overall lesion detection and analysis. The valueof tomosynthesis and ultrasound fusion imaging will be to provide additional clinical information in order to improvedecision making accuracy to either confirm or exclude a suspected abnormality and in particular detect small breastcancers.