Apparatus and procedure for processing clinical and biochemical data and three-dimensional ultrasound images to predict a woman's ovarian age and corresponding diagnostic ultrasound equipment

摘要

Apparatus (100) for processing clinical and biochemical data and three-dimensional (3D) ultrasound images to predict the ovarian age of women, comprising: - at least one functional block (101) configured to measure transvaginal ultrasound values of ovarian volume , of the antral follicle count (AFC), of the Vascularization Index (VI), of the caudal (FI), of the vascular flow index (VFI) of at least one woman; - and at least one functional block (102) configured to measure the hormonal values in blood of at least one woman comprised in the group consisting of the antimüllerian hormone (AMH), the follicle stimulating hormone (FSH), estradiol (E2), in women healthy for a period of time between the first and fourth day of the menstrual cycle; the output signals of said blocks (101, 102) being the input signals of a data processing block (103) based on a Generalized Linear Model (MLG) of processing consisting of a polynomial function to: - combine the parameters of antimüllerian hormone (AMH), follicle stimulating hormone (FSH), estradiol (E2), Antral follicle count (AFC), Flow Rate (FI), Vascularization Index (VI), vascular flow rate (VFI ) and ovarian volume, and - provide as a result of the polynomial algorithm output the value of ovarian age as a function of blood hormone values and transvaginal ultrasound values, measured in years and compared with the woman's age ; in which the polynomial function corresponds to the equation: ovarian age = c + a * AMH + b * bFSH + c * E2 + d * AFC + e * FI + f * VFI + g * Volume.