Biomimetic Graft-to And Graft-from Strategies For Micropatterning Nonfouling Domains On Surfaces

摘要

Many emerging biomaterials technologies including biosensors, implantable electrodes, and various diagnostic devices rely on materials capable of complex interfacial processes. For these applications, no longer is it sufficient to simply produce materials with surfaces that are ambiguously characterized as 'biocompatible'. Of increasing interest, is the development of materials which possess bioinert surfaces and at the same time are capable of specific interactions with the surrounding biological environment. In our previous investigations, we have demonstrated a novel approach inspired by mussel adhesive proteins to immobilize poly(ethylene glycol) (PEG) using 3,4-dihydroxyphynelalnine (DOPA) that is capable of robust attachment to Au and TiO_2, rendering them resistant to fouling by proteins and cells. In this study, we implement this PEGylation approach and a new biomimetic surface initiated atom transfer radical polymerization (SI-ATRP) method to prepare nonfouling micropatterns on biomaterial surfaces.