Relationship between the gene transfer efficacy and the facilitated disassembly of polyplexes composed of self- assembling amphiphilic polycations

摘要

In conclusion, it was found that DNA complexing with the copolymers having stearyl residues is much more easily replaced with added PVSK than the case of the linear-type copolymers. The amphiphilic copolymers were found to form micelle-like structure. These carriers promote the transcription caused by easiness of DNA release from the polyplexes and by less entanglement. These results suggest that the factor of carrier topology is important to deternine the expression efficiency.