Synergistic Effect of Silicon and Calcium Ions on Osteogenic Differentiation of Human Adipose Stem Cells

摘要

The present work shows that combining wet-spinning technology with a calcium silicate solution as a non-solvent allows designing scaffolds with key cues to render osteoconductive behaviour as the classic ceramic materials for bone regeneration. Additionally, these results suggests that Si and Ca ions may relevantly contribute to properly drive hASC towards the osteoblastic phenotype and highlight the potential of those ions together in the control of cellular response such as cell differentiation and/or in stem cells recruitment upon implantation of a cell-free scaffold.