Antibacterial Sol-Gel Films on Implant Material with Tailored Controlled Release Properties

摘要

The in vitro data demonstrate that thin and resorbable, long-term controlled release sol-gel films can be applied to Ti alloy substrates and that film resorption is the main mechanism underlying the control of release. This study suggests that the release rates and the film stability can be tailored to therapeutic needs by controlling film resorption rates. As such, silica sol-gel thin films can be used as a drug delivery system with potential clinical applications in prevention or treatment of periprosthetic infections.