Synthesis and chromatographic study of a novel csp for enantiomeric separation

摘要

A novel perfunctionalised cyclodextrin CSP immobilized onto aminized silica gel via a single ureido chemical bond was synthesized, exhibiting good enantiomeric separation abilities. A comparative study on the separation ability and separation-selectivity between the synthesized CSP column and the commercially available cyclodextrin-based column (CYCLOBOND I 2000 SN) was conducted. The results show that the ureido bonded CSP column depicted unique properties especially on the enantioseparation of beta -adrenergic blockers and amine-containing racemic compounds which is complementary to the CYCLOBOND column which can separate acidic compounds more effectively.