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THE FORMATION OF REACTIVE OXYGEN SPECIES DURING POLYCHLORINATED BIPHENYL METABOLISM IN HEPG2 CELLS

机译:HEPG2细胞中多氯联苯代谢过程中活性氧物种的形成

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摘要

The cellular toxicity of polychlorinated biphenyls (PCBs) quinones was investigated. It is proved that the exposure of PCB quinones cause oxidative damages in HepG2 cells, by loss of cell viability, free radicals and lipid peroxidation product generation, and the damage of antioxidant defense system. However, antioxidant DH-LA provides significant protection by against PCB quinones induced oxidative damages.
机译:研究了多氯联苯(PCBs)醌的细胞毒性。事实证明,PCB醌的暴露会引起HepG2细胞的氧化损伤,这是由于细胞活力的丧失,自由基和脂质过氧化产物的产生以及抗氧化防御系统的损伤。但是,抗氧化剂DH-LA可以有效抵抗PCB醌引起的氧化损伤。

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  • 来源
  • 会议地点 Chongqing(CN)
  • 作者单位

    Key Laboratory of Luminescence and Real-Time Analysis, Ministry of Education, College of Pharmaceutical Sciences,Southwest University, Chongqing 400715, China;

    Key Laboratory of Luminescence and Real-Time Analysis, Ministry of Education, College of Pharmaceutical Sciences,Southwest University, Chongqing 400715, China;

    Key Laboratory of Luminescence and Real-Time Analysis, Ministry of Education, College of Pharmaceutical Sciences,Southwest University, Chongqing 400715, China;

    Key Laboratory of Luminescence and Real-Time Analysis, Ministry of Education, College of Pharmaceutical Sciences,Southwest University, Chongqing 400715, China;

    Key Laboratory of Luminescence and Real-Time Analysis, Ministry of Education, College of Pharmaceutical Sciences,Southwest University, Chongqing 400715, China;

    Key Laboratory of Luminescence and Real-Time Analysis, Ministry of Education, College of Pharmaceutical Sciences,Southwest University, Chongqing 400715, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物工程学(生物技术);
  • 关键词

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