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Development of a stable and reproducible tissue-equivalent phantom for use in infrared spectroscopy and imaging

机译:研发出稳定且可复制的组织等效体模,用于红外光谱和成像

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Abstract: Much of the experimental work reported on the applications of near infrared spectroscopy and imaging for therapeutic purposes has been performed on multifarious tissue simulating materials, which often have unreproducible optical properties. To facilitate the quantitative testing of spectroscopy equipment, stable, reproducible phantoms which replicate the optical properties of tissue are needed. This paper describes one such phantom. The base material is a clear, non polymerized liquid polyester resin, which forms a solid on addition of a catalyst. The polyester has a low intrinsic absorption coefficient for infrared light and is nonscattering. Before the resin is set, measured quantities of scattering particle suspensions and absorbing dyes can be added. The scattering phase function of these particles has been measured, and the mean cosine of the scattering angle, g, calculated. Knowing this, by varying the concentration of scattering particles a range of materials with known transport scattering coefficients can be produced. By varying the concentration and mix of dyes, the absorption coefficient of the resin can be easily controlled. The resin can be easily machined or cast into arbitrary shapes, with regions of differing optical properties. Once set, the polyester is stable, in terms of both physical and optical properties. !41
机译:摘要:关于近红外光谱法和成像技术在治疗方面的应用的许多实验工作都是在多种组织模拟材料上进行的,这些材料通常具有不可复制的光学特性。为了促进光谱设备的定量测试,需要稳定,可复制的幻像,这些幻像复制组织的光学特性。本文描述了这样一种幻像。基材是透明的非聚合液态聚酯树脂,其在添加催化剂后形成固体。聚酯对红外光的固有吸收系数低,并且不散射。在固化树脂之前,可以添加一定量的散射颗粒悬浮液和吸收染料。已经测量了这些粒子的散射相位函数,并计算了散射角的平均余弦g。知道这一点,通过改变散射颗粒的浓度,可以产生具有已知传输散射系数的材料范围。通过改变染料的浓度和混合,可以容易地控制树脂的吸收系数。可以容易地将树脂加工或浇铸成具有不同光学特性区域的任意形状。一旦固化,聚酯就物理和光学性质而言都是稳定的。 !41

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