New optical method for noninvasive blood glucose measurement by optical ultrasonic modulation

摘要

A new optical technique for continuous, noninvasive monitoring of blood glucose levels based on ultrasonic modulation of scattering light is proposed. The ultrasound-modulated scattered light has an accurate separation of scattering and absorption changes in tissue. And the optical scattering and absorbing coefficient of tissue depend on the concentration of glucose in the extracellular fluid. As the glucose induced to scattering and absorption changes, the ultrasound-modulated light also changes. In this paper, a correlation is observed between ultrasound-modulated light intensity as well as its modulation depth and blood glucose concentration in phantom experiments. In addition, some researches about ultrasound-modulated signal affected by the temperature of glucose aqueous solution are done. Preliminary experiments find that this method is a promising noninvasive blood glucose measurement.