Method and apparatus for noninvasive optical measurement of glucose concentration in flowing blood in vivo

摘要

The present invention relates to a method and apparatus for noninvasively optically measuring a glucose concentration in blood flowing in one blood vessel inside a body in vivo. The body is illuminated by an ultrasonic beam having an ultrasonic frequency to mark a blood vessel, the body having the blood vessel is illuminated with light having at least one first light wavelength, the first light; In the case of wavelength, the intensity of backscattered light depends on the glucose concentration, and the body having the blood vessel is illuminated with light of a second light wavelength that is within the range of the water absorption spectral line, and the water absorption A plurality of signal components, the position of the spectral lines depending on the temperature of the blood, the respective backscattered light being acquired by at least one detector and modulated by a modulation frequency depending on the ultrasonic frequency Are each extracted by an evaluation device from a plurality of detector signals measured by the detector, and an index value for the glucose concentration is Is calculated from the detected signal components in the case of the light wavelength, the index value is corrected by the signal component of the second optical wavelength in order to correct the temperature dependency.