Enhanced bioavailability of peptide YY using nanoporous silicon as a drug carrier

摘要

In the present study, we have used nanoporous silicon microparticles as drug carriers to improve anti-obesity peptide YY3-36 (PYY) delivery. Three different surface chemistries were used and PYY plasma concentrations were analyzed after subcutaneous injections as a function of time. Sustained release of PYY was obtained with all the three surface chemistries, but with a thermally oxidized surface, 2.5-fold increase in bioavailability was observed. Terminal half-lives were also significantly changed from the initial 25 min of PYY solution up to 21 h indicating a strong influence of PSi carriers on the in vivo pharmacokinetics of PYY.