鱼类肽YY与胰肽Y的研究进展

摘要

Peptide YY (PYY) and pancreatic peptide Y (PY) in family of pancreatic polypeptide,are multi-functional regulatory peptide are distributed widely.The fish specific PY is the duplication ofPYY.PYY and PY genes have been identified in many fishes,binding to corresponding receptprs,play physiological function including full feeding feeling leading to low appetite and loss in body weight.PYY and PY play important roles in regulating fish feeding,improvement of food conversion efficiency,promoting healthful aquaculture and treating in digestive tract,hepatopancreas and obesity disease.The fish PYY and PY architectural feature,distribution in the body,modality,receptprs,influence factors and biological function are reviewed to offer some reference in the further research of fish PYY and PY.%酪酪肽与胰肽Y同属于胰多肽家族,是广泛存在的多功能调节肽;胰肽Y是酪酪肽基因组复制产生的鱼类中特有的神经肽.目前已在多种鱼类中分离得到酪酪肽与胰肽Y的基因,与特定受体发挥生理功能,包括使机体产生饱腹感而食欲下降,减少摄食,降低体质量,在调控养殖鱼类摄食,提高饲料转化率,促进鱼类健康养殖以及消化道、肝胰腺、肥胖等治疗方面发挥重要作用.本文通过概述鱼类中酪酪肽与胰肽Y的结构特征、体内分布、作用的形式及受体、影响因素等生物学功能,为鱼类肽YY及胰肽Y的研究提供参考.