Preparation, Characterization and Antioxidative Activity of Anti-aging Nanoemulsion and Lipid Nanoparticles

摘要

Nanoemulsions (NEs) and Lipid Nanoparticles(LNs) are regarded as suitable nanosized carriers of water-insoluble active components such as Alpha Lipoic Acid (ALA), Coenzyme Q10 (CoQ10) and Vitamin E (VE) to improve the physical and chemical stabilities of active components. Good physical and chemical stability of particles was proved by Photon Correlation Spectroscopy (PCS), Laser Diffraction (LD), viscosity and UV/HPLC with different storage times. UV/HPLC measurements showed that the loading capacity of active after production could reach 10% for ALA, 8% for CoQ10 and 10% for VE. The high entrapment efficiency (nearly 100%) was obtained for all formulations. Through study on inhibition rate of anti-aging active components to free radical, good antioxidant activity of ALA and CoQ10was determined.