Translational Nano-Medicine: Targeted Delivery Systems for Cancer and Inflammatory Diseases

摘要

1.There is a significant need to facilitate clinical translation of advances in molecular medicine into effective disease diagnosis and therapeutic strategies. 2.Nanotechnology has an important role to play in disease diagnosis, imaging, and therapy and potentially may advance personalized medicine. 3.In cancer, we are interested in reprogramming with exosome-mediated tumor microenvironment with genetic therapies using combinatorial-designed hyaluronic acid-based nanoparticles platform. 4.For anti-inflammatory therapy, we are evaluating macrophage repolarization approaches and have evaluated IL-10 and microRNA-223 delivery and transfection using CD44 targeting hyaluronic acid nanoparticles. 5..For each example, our focus is on solving important medical problems with innovative solutions that use inexpensive and safe materials, as well as, scalable fabrication methods so that these promising experimental technologies are realized in the clinic in the near future.