Preliminary studies of new photosensitizer for photodynamic treatment of melanoma based on nanostructural forms of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester

摘要

Method of photodynamic therapy (PDT) of malignancies is actively used in experimental and clinical oncology. This work is devoted to investigation of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester which possesses its absorption band at 795-800 nm. We have estimated the applicability of PDT with this photosensitizer to treat melanoma.rnWe have developed nanostructural forms of the substance - micellar dispersions on a base of 4% aqueous solution of Cremophor EL and Emuxol-268 and PEG-liposomal dispersion.rnIn all forms photosensitizer was selectively accumulated in tumor in comparison to normal tissue. PDT on BDF, mice bearing B16 melanoma have shown high therapeutic efficiency with inhibition of tumor growth up to 91%, increase of animal lifespan exceeded 60%. Complete recovery was achieved for 35% of animals.