Diffuse reflectance of cervical tissue treated with gold nanoshells is collected at 0 and 40 degrees, measured from the perpendicular to tissue surface. Between the two collection angles, the infused nanoshells exhibit much stronger scattering signals in contrast to the ordinary reflectance attributed to the naked tissue when the collection angle of the fiber probe is obliquely oriented at 40 degrees. At 0 deg. Fiber angle, no significant differentiation is observed between naked and nanoshell-treated tissue samples. This result indicates a strong potential of combining angularly-variable reflectance spectroscopy and gold nanoshells in order to achieve synergistically enhanced scattering contrast in tissue.
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