Prenatal Exposure to Bisphenol A and Childhood Neurodevelopment in Shandong, China

摘要

Background: Experimental and epidemiological studies suggest that prenatal exposure to Bisphenol A (BPA) may interfere with children neurodevelopment. However, current evidence was inconsistent and relevant study from China is limited. Methods: Based on a cohort in northern China, BPA concentrations were measured among 506 pregnant women and neurodevelopment was assessed using the Gesell Development Schedules for their children at 12 months (n=368) and 24 months (n=296). Linear regression and generalized linear models were used to analyze the association between prenatal BPA exposure and children's developmental quotients (DQs). Results: The median of maternal BPA concentrations were 0.48ug/L or 1.05ug/g creatinine. Prenatal BPA levels were adversely associated with children's DQ scores at 12 months of age, with a 10-fold increase in prenatal BPA levels correlated to 1.43-point decrease in adaptive domain DQs (95%CI: -2.30 to -0.56, p=0.001). When stratified by child gender, prenatal BPA concentrations were adversely associated with the DQs on adaptive domain among boys and the DQs on adaptive domain and social domain among girls. No association was found between prenatal BPA exposure and children's DQs at 24 months of age. Conclusion: Based a Chinese population, we demonstrated potential impacts of prenatal BPA exposure on neurodevelopment for children at 12 months of age, which differ between child age and gender.