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Multifunctional Scaffold for the Delivery of Neural Stem Cells to Promote Regeneration after Traumatic Brain Injury

机译:用于递送神经干细胞的多功能支架,以促进创伤性脑损伤后的再生

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In this study, we have designed and optimized 3D multifunctional microspheres using natural biopolymers for the delivery of neural stem cells and growth factors into the injured CNS. Heparin was stably cross-linked onto the chitosan scaffolds using genipin. The cross-linked chitosan-heparin complex was shown to have a high binding affinity for FGF-2 and supported the growth of neural stem cells.
机译:在这项研究中,我们使用天然生物聚合物设计和优化的3D多功能微球,用于将神经干细胞和生长因子输送到受伤的CNS中。使用Genipin将肝素与壳聚糖支架稳定交联。显示交联的壳聚糖 - 肝素复合物对FGF-2具有高结合亲和力并支持神经干细胞的生长。

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