IR spectrum comparison of the blood of breast cancer patients as a preliminary stage of further molecular genetic screening

摘要

The aim of this paper is to study BRCA1 - 185delAg and 5382insC gene mutations in breast cancer patients and their relatives to identify new directions for the prevention, diagnosis and treatment of breast cancer. As diagnostic methods have been used ultraviolet spectrometry samples of blood plasma in the liquid state, infrared spectroscopy middle range (2,5 - 25 microns) dry residue of plasma polarization and laser diagnostic technique of thin histological sections of biological tissues. Obtained results showed that the use of spectrophotometry in the range of 1000-3000 cm-1 allowed to establish quantitative parameters of the plasma absorption rate of blood of patients in the third group in different ranges, which would allow in the future to conduct an express analysis of the patient's condition (procedure screening) for further molecular-genetic typing on BRCA Ⅰ and Ⅱ.