Thermal interaction of biological tissue with nanoparticles heated by laser radiation

摘要

We explore the problem of thermal interaction of nanoparticles heated by laser radiation with a biological tissue after particle flow entering the cell. The solution of the model equations is obtained numerically under the following assumptions: a single particle is located in a neighborhood exceeding the particle size; the environment surrounding the particle is water with the conventional thermal characteristics. The model equations are deduced from the particle and the environment energy conditions taking into account the heat transfer in the particle and in its environment by conduction. We also assume that at the boundary between the particle and the surrounding water the perfect thermal contact takes place. The numerical solution of the problem is carried out with the use of an implicit difference scheme and the sweep method. Two cases of the laser pulse action on a particle are considered: a single pulse and a series of pulses. The dynamics of the temperature isoline propagation is obtained at which protein denaturation occurs in the space around the metal nanoparticle in the cases when the particles are heated by a single pulse and a series of pulses. The dependence of the heating rate and the heating depth of the medium on the laser pulse repetition frequency is found.