COMPARATIVE EVALUATION OF SODIUM DICLOPHENAC AND NICOTINAMIDE IN VITRO DRUG DELIVERY FROM PHOSPHATED CROSSLINKED HIGH AMYLOSE.

摘要

High amylose was cross-linked at different degrees and the performance of these products as non compacted drug delivery systems was evaluated for two drugs with different characteristics (sodium diclophenac and nicotinamide). All samples with cross-linked polymers showed increased drug release time compared to those with non cross-linked polymers. Sodium diclophenac presented a lower release rate, due to its smaller molecule size that prevents its effective entrapment with in to the polymer meshes, and also due to its chemical structure, that favors weaker linkages with the polymer backbone.