Prediction of plasma drug concentration after oral administration of cylindrical matrices

摘要

The aim of this work is to model the process of in vivo drug release and absorption from not swellable, not erodible cylindrical matrices composed of four uniform zones, each one of them having different density, porosity, mesh size and drug concentration. This requires the three-dimensional solution of the mass conservation law. Our simulations indicate that drug release and absorption strongly depend on matrix properties. Accordingly, this model represents a simple and practical tool for rationalizing in vivo drug release and absorption following oral administration of cylindrical matrices.