Prediction of plasma drug concentration after oral administration of cylindrical matrices

摘要

The aim of this work is to model the processof in vivo drug release and absorption from notswellable, not erodible cylindrical matricescomposed of four uniform zones, each one ofthem having different density, porosity, meshsize and drug concentration. This requires thethree-dimensional solution of the massconservation law. Our simulations indicate thatdrug release and absorption strongly depend onmatrix properties. Accordingly, this modelrepresents a simple and practical tool forrationalizing in vivo drug release and absorptionfollowing oral administration of cylindricalmatrices.