Modulation of Drug Release in Poly( ε-caprolactone) Blend Microfibers -

摘要

Electrospun poly(ε-caprolactone), PCL based microfibers were obtained by electrospinning of 15 % polymer solutions at 20 kV. Timolol maleate and acetazolamide (both anti-glaucoma drugs) were loaded in the fibers at different concentrations. Sustained release was observed during 1 month for PCL samples, while burst was shown by blends. Drug loading and drug solubility in the polymers affect the drug state in the fibers and drug release. Desorption and degradation models equations were fitted to the release data to understand the phenomena involved in the release process.