Pharmacokinetic of vancomycin in the pretime newborn with ventilator-associated pneumonia

摘要

The levels of vancomycin were studied in serum blood and trachea-bronchial aspirations (TBA) after an intravenous infusion of 20 mg/kg in 12 pretime newborns with "ventilation-associated" pneumonia (VAP). Maximum concentration of vancomycin in serum blood was in 30 minutes (120-165 mcg/ml) with falling ad 0,5 - 12 mcg/ml in 12 hours. T1/2 (semi removal) made 1-3,8 hours. The excess of minimal inhibiting concentration (MIC) in blood were 10 hours among all children, and 12 hour MIC were only among 5 children. The antibiotic was found in TBA after 30 min. in quantity of 1,5 - 30 mcg/ml. The increase of this level was during 2 hour until 4-34 mcg/ml. These levels stayed until 3 -7 hour, but than they fall till 0,5-1,5 mcg/ml to 12 hours.