TNF siRNA as Modulators of Apoptosis and Angiogenesis, in Cell Migration and Invasion in Triple Negative Breast Cancer Cells (TNBC)

摘要

Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that has been linked to breast cancer development. Estrogen metabolic pathway is also involved in breast carcino-genesis and DNA adducts formation. A particular case is the TNF- α modulation in TNBC (triple negative breast cancer). Currently there are several TNF-α antagonists applied in clinical use and these agents have provided significant benefits for a variety of cancers. In the last years a special interest have received triple negative breast cancer which is a highly aggressive subtype that observed particularly in young patients with a poor overall survival rate and no target therapy.