Nanopartkles for Peptide Synthesis and Biological Applications

摘要

Developing new methods for in vivo targeting and tracking of small molecules in live cells is crucial for extending the scope of a variety of biological applications such as drug discovery, drug targeting, medical diagnostics and tissue engineering. To develop advanced systems for live cell and in vivo screening based on the use of small molecules anchored to inert vehicle particles, we have synthesized a new type of biocompatible, non-toxic nanoparticles (NPs) suited both for synthesis of peptides on their surface and for live cells and in vivo applications. These new NPs can be used for novel generations of screening systems where a small molecule is synthesized on or conjugated to bio-compatible and properly labeled NPs so that it can be further screened/tracked in live-cell assays or even in vivo without toxicity risks originated from the vehicle particle.