Icosahedral Cobalt Bis(dicarbollide) Ions with Bridge Linker and Their Electrochemistry in Aqueous Media

摘要

Boron cluster compounds (BCC) proved recently promising properties for use in drug design and molecular probes. Their applications in medicine are inherently connected with use of water-based environments. Up to now, the BCC were predominantly characterized in non-aqueous milieus. Therefore, we decided to perform electrochemical research of BCC in water-based electrolytes. We have focused on several boron clusters with structures that follow our previous study on icosahedral cobalt bis(dicarbollide) ions with a central coordination Co(III) atom in phosphate buffers, where we have found the best response for bridge type of exo-skeletal substituent. Therefore, in present study, we decided to focus on the promising structures, in which two 11 vertexes C_2B_9 dicarbollide ligands are interconnected via short bridge. Such structures may contain side chains usable for bioconjugation experiments.