PEG-amylin fragments as models for conformational studies

摘要

Islet amyloid peptide or amylin(IAPP)has been referred to as the main component of the fibrous protein aggregates present in the pancreas of patients with severe hyperglycemia.Such amyloid plaques are a characteristic histopathological marker in over 90% of all cases of type-2 diabetes.Mature amylin IAPP is a 37-residue peptide synthesized in the pancreas and it co-localizes with insulin in beta-cell dense core secretory granules.Due to its co-secretion with insulin,amylin has been suggested to play some role in regulating the blood level glucose by controlling insulin release.