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PEG-amylin fragments as models for conformational studies

机译:PEG-淀粉蛋白片段作为构象研究的模型

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Islet amyloid peptide or amylin(IAPP)has been referred to as the main component of the fibrous protein aggregates present in the pancreas of patients with severe hyperglycemia.Such amyloid plaques are a characteristic histopathological marker in over 90% of all cases of type-2 diabetes.Mature amylin IAPP is a 37-residue peptide synthesized in the pancreas and it co-localizes with insulin in beta-cell dense core secretory granules.Due to its co-secretion with insulin,amylin has been suggested to play some role in regulating the blood level glucose by controlling insulin release.
机译:胰岛淀粉样肽或淀粉蛋白(IAPP)被称为存在于患有严重高血糖血症患者胰腺中存在的纤维蛋白质聚集体的主要成分是淀粉样蛋白斑块的胰腺斑块,是所有2型患者的90%以上的特征组织病理学标志物 糖尿病。Acapath Iapp是一种37残基肽,在胰腺中合成,它与胰岛素浓密核心分泌颗粒中的胰岛素共定。与胰岛素的共同分泌,淀粉蛋白已建议在调节中发挥作用 通过控制胰岛素释放来血液水平葡萄糖。

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