Disodium Salt of 2-(5-phenyl-1, 3, 4-oxadiazol-2-yl) Phenyl Phosphate as a Fluorescent Probe for Determination of ALP

机译：2-（5-苯基-1,3,4-恶二唑-2-基）磷酸二钠盐作为荧光探针，用于测定ALP

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A convenient method to synthesize disodium salt of 2-(5-phenyl-1, 3, 4-oxadiazol-2-yl) phenyl phosphate (OXDP), a substrate for the fluorescent determination of alkaline phosphatase (ALP) activity, via an one-pot procedure of condensation between the benzoic acid and 2-hydroxybenzhydrazide at triethylamine alkaline solution in the presence of propylphosphonic anhydride, was realized. Preliminary tests reveal that the lessened fluorescence intensity resulting from enzyme reaction is proportional to ALP activity in the range of 1.0-25.0 U/L with the detection limit of 0.25U/L, which can be successfully applied to assess ALP in human serum with good precision.

机译：合成2-（5-苯基-1,3，4-恶二唑-2-基）苯基磷酸盐（OXDP）的二钠盐的方便方法，通过一个实现了丙基胺碱溶液在丙基膦酸酐的三乙胺碱性溶液中苯甲酸和2-羟基苯并肼之间的缩合的缩合程序。初步测试表明，酶反应产生的减少的荧光强度与1.0-25.0 U / L的AlP活性成比例，其检测限为0.25u / l，可以成功地应用于用良好的人血清评估ALP 精确。

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《ICAMME 2011;International Conference on Applied Mechanics and Mechanical Engineering》|2012年||共6页
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Lei Yingjie; Ouyang Jie; Ding Mei;
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中图分类 78.083;
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ALP; fluorescent probe; 2-(5-phenyl-1; 3; 4-oxadiazol-2-yl)phenol; synthesis;

机译：铝;荧光探针;2-（5-苯基-1;3;4-恶二唑-2-基）苯酚;合成;

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3. Synthesis of 2-(1 H-Benzo[d]imidazol-2-yl)phenyl Phosphate as a Fluorescent Probe for Determination of ALP [J] . LEI Yingjie, OUYANG Jie, ZHANGYoulai, 中国化学（英文版） . 2009,第012期
4. Disodium Salt of 2-(5-phenyl-1, 3, 4-oxadiazol-2-yl) Phenyl Phosphate as a Fluorescent Probe for Determination of ALP [C] . Lei Yingjie, Ouyang Jie, Ding Mei International Conference on Applied Mechanics and Mechanical Engineering . 2012

机译：2-（5-苯基-1,3,4-恶二唑-2-基二烷基）的二钠盐作为荧光探针，用于测定ALP
5. Effect of electric current on the stability of aqueous solution of amitriptyline HCl, amoxicillin, cefuroxime sodium and dexamethasone 21 phosphate disodium salt. [D] . Patel, Gaurav I. 2009

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6. Crystal structures of the hexafluoridophosphate salts of the isomeric 2- 3- and 4-cyano-1-methylpyridinium cations and determination of solid-state interaction energies [O] . Joel T. Mague, Erin Larrabee, David Olivier, 2018

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7. 2-[3,4-Dibutoxy-5-(5-phenyl-1,3,4-oxadiazol-2-yl)-2-thienyl]-5-phenyl-1,3,4-oxadiazole [O] . Li, Hai-lin, Zeng, Hai-su, Kang, Si-shun, 2008

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Disodium Salt of 2-(5-phenyl-1, 3, 4-oxadiazol-2-yl) Phenyl Phosphate as a Fluorescent Probe for Determination of ALP

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