Automatic Production Process of Erythropoientin

摘要

The System includes a culture rack station for storing a large number of roler bottles filled with culture medium and inoculated with mammalian cells, masshadnling facility for exracting completed cultures from the roller bottles, and repalcing the culture medium. The varous component units of the system were controlled either by a general-purpose programmable logic controller or a dedicated controller. The operator could easily select and change the appropriate mode from outside of the aseptic area. The development of the system made large-scale production of mammalian cells, and manufacturing and stabilization of high quality products such as erythropoietin possible under total aseptic control, and opened up the door for industrial production of physiologially active substances as pharmaceutical drugs by mammalian cell culture.