Mathematical Modelling of Magnesium Block-Driven NMDA Receptor Response in CA1 Pyramidal Neuron for Alzheimer's Disease

摘要

N-methyl-D-aspartate receptors(NMDA)located on the postsynaptic terminal of CA1 pyramidal neuron plays an essential role in synaptic plasticity,and the calcium(Ca)current flowing through it drives several intracellular calcium mechanisms.We have developed a single-compartment model involving least mechanisms to study the NMDA receptor response to different input condition and to obtain the voltage-dependent relationship of magnesium(Mg)block in the NMDA receptor.Using this interdependence,we have replicated a pathological condition of Alzheimer's diseases(AD)to obtain total NMDA receptor current in AD.The results obtained at different Mg concentration suggested that the blocking rate increases linearly with the Mg concentration.In AD,there is dysfunction of Mg block which leads to the early opening of the NMDA receptor.So,using a drug which controls the blocking mechanism of Mg leads to control of NMDA receptor current.This results in the control of intracellular Ca current.